▲ Newly Upgraded [2022 Summer] Advanced Customized CRISPR Gene Editing Research Project 爱博物
【Project Upgrade】
Building upon IBOWU's classic CRISPR gene editing program in fish, this edition has been enhanced with updated experimental content and project design, aligning with cutting-edge trends in gene therapy. The project now utilizes viral vectors for gene editing, enabling students to study and research CRISPR/Cas9-based gene therapy.
Gene therapy using viral vectors is one of the most advanced approaches in the field today. Dozens of such therapies have been approved globally, demonstrating promising results in treating diseases once considered incurable.
【Project Introduction】
Cornell University geneticist John Schimenti once remarked that, throughout his scientific career, he has witnessed two major technological advancements: PCR technology and CRISPR gene editing technology.
PCR technology, developed in 1985, revolutionized genetic engineering by enabling gene amplification. The emergence of CRISPR technology promises to bring even more profound changes to the life sciences.
▲Activating CRISPR-Cas9 Protein via Guide RNA Binding
As a leading gene editing technology, CRISPR/Cas9 is recognized for its efficiency and precision in editing genes within living cells. It allows for targeted deletion, insertion, or modification of specific DNA segments. Advances in gene editing technology hold the potential to eradicate human diseases, create hardier plants, and eliminate pathogens.
▲Lentivirus-Transfected Human HEK293 Cells
Guided by frontline research experts from BGI, students will gain hands-on experience and a deep understanding of this groundbreaking technology.
▲Experimental Process of Lentivirus Transfection in Cells
▲ Lentivirus Life Cycle
In this customized research project, students will not only learn about the latest advancements in CRISPR technology but also apply it practically under the guidance of BGI's research team. By performing gene editing operations themselves, students will develop a scientific mindset, master research methodologies, and lay a foundation for future advanced studies and independent research projects.
▲ Microinjection is one of the most challenging and precise experimental techniques in gene editing experiments
【Course Time】 July 15–20, 2022
【Recommended Grades】 6–8
【Planned Enrollment】 12–15 students
【Location】 National Ocean Gene Bank, Qingdao, China
【Location】 National Ocean Gene Bank, Qingdao, China
The National Ocean Gene Bank is a comprehensive gene bank integrating marine biological resource collection and marine life digitization. It is the only such national-level marine gene bank currently under construction globally. Its synthesis and editing platform features state-of-the-art hardware and software capabilities.
▲National Ocean Gene Bank Laboratory Platform
【Mentor Team】
The mentor team is led by young scientists from the JSR Academic Committee and consists of professional researchers from the National Ocean Gene Bank and the Qingdao BGI Research Institute. Their expertise spans synthetic biology, molecular biology, bioinformatics, and other fields.
Academic Advisors:
Ms. Zhang: +86 13910908618 (WeChat ID same as phone number)
Ms. Zha: +86 13910312020 (WeChat ID same as phone number)
About IBOWU · JSR Academy
JSR Academy™ is China’s first youth science academy initiated by non-governmental forces. Launched by IBOWU, a renowned platform for youth scientific research and academic programs in China, it aims to provide high-quality scientific practice projects for Chinese youth.
IBOWU has received investments from BGI Group and TAL Education Industry Fund. Leveraging strong scientific and capital backing, JSR Academy has gathered dozens of multidisciplinary frontline scientists and partnered with numerous university and research institution laboratories across China, the U.S., Denmark, Norway, Singapore, Australia, and other countries. It is dedicated to offering advanced STEM academic programs and elite training plans for students, fostering a scientific spirit among Chinese youth, and contributing to the reserve of scientific and technological talent for China and the world.
